Biomolecular Networks for Complex Diseases

Biomolecular Networks and Human Diseases

1 Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9 2Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A9 3 Collaborative Research Center for Innovative Mathematical Modelling, Institute of Industrial Science, University of Tokyo, Tokyo 153-8505, Japan 4Key Laboratory of Systems Biology, Shanghai Institutes f...

Randić index, irregularity and complex biomolecular networks.

A new formulation of Randić index is carried out as a minimization of a quadratic form which involves the Laplacian matrix of a graph. Using this formulation it is easy to realize that Randić index is useful in defining a new index of irregularity, which is then formulated here. A new context for the study of irregularity of graphs is advanced as a necessity for studying complex (biological) ne...

Complex biomolecular networks: challenges and opportunities.

Complex biomolecular networks: challenges and opportunities

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Identifying critical transitions and their leading biomolecular networks in complex diseases

Identifying a critical transition and its leading biomolecular network during the initiation and progression of a complex disease is a challenging task, but holds the key to early diagnosis and further elucidation of the essential mechanisms of disease deterioration at the network level. In this study, we developed a novel computational method for identifying early-warning signals of the critic...